《英文msh詞典》Controlled Repressor,Heme
[入口詞] Controlled Repressor,Heme
[主題詞] eIF-2 Kinase
[英文釋義] A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP,EUKARYOTIC INITIATION FACTOR-2 kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2,leading to the inhibition of protein synthesis.